| Autor: |
Heaney, Liam G. de Llano, Luis Perez Al-Ahmad, Mona Backer, Vibeke Busby, John Canonica, Giorgio Walter Christoff, George C. Cosio, Borja G. FitzGerald, J. Mark Heffler, Enrico Iwanaga, Takashi Jackson, David J. Menzies-Gow, Andrew N. Papadopoulos, Nikolaos G. Papaioannou, I, Andriana and Pfeffer, Paul E. Popov, Todor A. Porsbjerg, Celeste M. Rhee, Chin Kook Sadatsafavi, Mohsen Tohda, Yuji Wang, Eileen and Wechsler, Michael E. Alacqua, Marianna Altraja, Alan and Bjermer, Leif Bjornsdottir, Unnur S. Bourdin, Arnaud and Brusselle, Guy G. Buhl, Roland Costello, Richard W. Hew, Mark Koh, Mariko Siyue Lehmann, Sverre Lehtimaki, Lauri and Peters, Matthew Taille, Camille Taube, Christian Tran, Trung N. Zangrilli, James Bulathsinhala, Lakmini Carter, Victoria A. Chaudhry, Isha Eleangovan, Neva Hosseini, Naeimeh and Kerkhof, Marjan Murray, Ruth B. Price, Chris A. Price, David B. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Popis: |
BACKGROUND: Phenotypic characteristics of patients with eosinophilic and noneosinophilic asthma are not well characterized in global, real-life severe asthma cohorts. RESEARCH QUESTION: What is the prevalence of eosinophilic and noneosinophilic phenotypes in the population with severe asthma, and can these phenotypes be differentiated by clinical and biomarker variables? STUDY DESIGN AND METHODS: This was an historical registry study. Adult patients with severe asthma and available blood eosinophil count (BEC) from 11 countries enrolled in the International Severe Asthma Registry (January 1, 2015-September 30, 2019) were categorized according to likelihood of eosinophilic phenotype using a predefined gradient eosinophilic algorithm based on highest BEC, long-term oral corticosteroid use, elevated fractional exhaled nitric oxide, nasal polyps, and adult-onset asthma. Demographic and clinical characteristics were defined at baseline (ie, 1 year before or closest to date of BEC). RESULTS: One thousand seven hundred sixteen patients with prospective data were included; 83.8% were identified as most likely (grade 3), 8.3% were identified as likely (grade 2), and 6.3% identified as least likely (grade 1) to have an eosinophilic phenotype, and 1.6% of patients showed a noneosinophilic phenotype (grade 0). Eosinophilic phenotype patients (ie, grades 2 or 3) showed later asthma onset (29.1 years vs 6.7 years; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
