| Popis: |
A series of alkylaminoalkyl esters and amides of 2-hydroxy-(or alkoxy-)3-methoxybenzoic acid were synthesized and their hydrochloride, methiodide, or oxalate salts were tested for local anesthetic activity. Only the diethylamino and n-butylamino ethyl esters of 2-butoxy-3-methoxybenzoic acid and morpholinoethyl 2-ethoxy-3-methoxybenzoate exhibited greater local anesthetic activity than lidocaine. However, these compounds were highly irritating and generally more toxic. © 1969, American Chemical Society. All rights reserved. |
