| Autor: |
Stevens, Kristen N. Vachon, Celine M. Lee, Adam M. Slager, Susan Lesnick, Timothy Olswold, Curtis Fasching, Peter A. and Miron, Penelope Eccles, Diana Carpenter, Jane E. Godwin, Andrew K. Ambrosone, Christine Winqvist, Robert Brauch, Hiltrud Schmidt, Marjanka K. Cox, Angela Cross, Simon S. and Sawyer, Elinor Hartmann, Arndt Beckmann, Matthias W. and Schulz-Wendtland, Ruediger Ekici, Arif B. Tapper, William J. and Gerty, Susan M. Durcan, Lorraine Graham, Nikki Hein, Rebecca and Nickels, Stephan Flesch-Janys, Dieter Heinz, Judith and Sinn, Hans-Peter Konstantopoulou, Irene Fostira, Florentia and Pectasides, Dimitrios Dimopoulos, Athanasios M. Fountzilas, George Clarke, Christine L. Balleine, Rosemary Olson, Janet E. Fredericksen, Zachary Diasio, Robert B. Pathak, Harsh and Ross, Eric Weaver, JoEllen Ruediger, Thomas Forsti, Asta and Duennebier, Thomas Ademuyiwa, Foluso Kulkarni, Swati and Pylkaes, Katri Jukkola-Vuorinen, Arja Ko, Yon-Dschun Van Limbergen, Erik Janssen, Hilde Peto, Julian Fletcher, Olivia and Giles, Graham G. Baglietto, Laura Verhoef, Senno and Tomlinson, Ian Kosma, Veli-Matti Beesley, Jonathan Greco, Dario Blomqvist, Carl Irwanto, Astrid Liu, Jianjun and Blows, Fiona M. Dawson, Sarah-Jane Margolin, Sara Mannermaa, Arto Martin, Nicholas G. Montgomery, Grant W. Lambrechts, Diether Silva, Isabel dos Santos Severi, Gianluca Hamann, Ute Pharoah, Paul Easton, Douglas F. Chang-Claude, Jenny and Yannoukakos, Drakoulis Nevanlinna, Heli Wang, Xianshu Couch, Fergus J. GENICA Consortium |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
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| Popis: |
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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