| Autor: |
Rapti, Vassiliki Moirogiorgou, Evangelia Koliou, Georgia-Angeliki Papadopoulou, Kyriaki Binas, Ioannis and Pentheroudakis, George Bafaloukos, Dimitrios Bobos, Mattheos and Chatzopoulos, Kyriakos Chrisafi, Sofia Christodoulou, Christos and Nicolaou, Irene Sotiropoulou, Maria Magkou, Christina and Koutras, Angelos Papakostas, Pavlos Kotsakis, Athanasios and Razis, Evangelia Psyrri, Amanda Tryfonopoulos, Dimitrios and Pectasides, Dimitrios Res, Eleni Alexopoulos, Athanasios and Kotoula, Vassiliki Fountzilas, George |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Popis: |
Prognostic and predictive biomarkers are being studied for the diagnosis and treatment of breast cancer. The present study retrospectively assessed the mRNA expression of HER family receptor ligands and of other potential prognostic biomarkers and their association with time to progression (TTP), survival and clinicopathological characteristics in patients with metastatic breast cancer (MBC) treated with trastuzumab. A total of 145 tumour tissue samples were analysed. mRNA expression analysis of the transcripts of interest was performed and the association of these markers with selected clinicopathological parameters was examined. HER2 status was centrally re-evaluated. Only 67.6% of patients were truly HER2-positive according to the central HER2 re-evaluation. Heparin binding epidermal growth factor (EGF)-like growth factor, transforming growth factor beta 1 (TGFB1) and thyroid hormone receptor alpha (THRA) mRNA expression was higher in HER2-positive patients (P=0.026, P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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