| Popis: |
The role of red cell 2,3‐diphosphoglycerate (2,3‐DPG) in increasing the availability of haemoglobin oxygen in neonatal jaundice and hereditary haemolytic anaemias was investigated. Measurements of 2,3‐DPG were carried out on 58 normal children and six normal adults, 18 full‐term newborns with neonatal jaundice and 57 cases (51 children and six adults) with hereditary haemolytic anaemias. In normal children and adults, with a mean haemoglobin of 12.69 g/dl, mean 2,3‐DPG was 14.90 μmol/g Hb. In jaundiced newborns with a mean haemoglobin of 16.04 g/dl mean 2,3‐DPG levels were 14.51 μmol/g Hb, i.e. normal. 2,3‐DPG levels were increased in patients with β‐thalassaemia major, α‐thalassaemia, sickle‐cell disease, favism, hereditary spherocytosis and in heterozygotes for β‐thalassaemia with increased haemoglobin F. In heterozygotes for β‐thalassaemia with increased haemoglobin A2 only and in sickle cell trait 2,3‐DPG levels were normal. Copyright © 1975, Wiley Blackwell. All rights reserved |
