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Multiple myeloma is characterized by accelerated production of the proteolytic enzyme matrix metalloproteinase (MMP)-9. We hypothesized that myeloma-produced MMP-9 may influence the rate of bone turnover in a paracrine manner. Thus, we examine the correlations of MMP-9 levels, disease severity, and bone turnover rate as evaluated by markers of bone formation and resorption. Thirty-seven newly diagnosed multiple myeloma patients (nine of Durie-Salmon stage I, 12 of stage II and 16 of stage III) and 12 age-matched controls were studied. Serum MMP-9 levels were significantly higher at stage II compared to stage I (188.78 +/- 91.27 vs. 59.25 +/- 33.09 ng/mL, p < 0.004). Additionally, free urine pyriclinolines (F-Pyd), free urine deoxy-pyridinolines (F-Dpd) and urine N-telopepticle fragment (NTx) were elevated, their level correlating. with disease stage (p |
