| Autor: |
Garbis, Spiros D. Tyritzis, Stavros I. Roumeliotis, Theodoros and Zerefos, Panagiotis Giannopoulou, Eugenia G. Vlahou, Antonia and Kossida, Sophia Diaz, Jose Vourekas, Stavros and Tamvakopoulos, Constantin Pavlakis, Kitty Sanoudou, Despina and Constantinides, Constantinos A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Popis: |
This study aimed to identify candidate new diagnosis and prognosis markers and medicinal targets of prostate cancer (PCa), using state of the art proteomics. A total of 20 prostate tissue specimens from 10 patients with benign prostatic hyperplasia (BPH) and 10 with PCa (Tumour Node Metastasis [TNM] stage T1-T3) were analyzed by isobaric stable isotope labeling (iTRAQ) and two-dimensional liquid chromatography-tandem mass spectrometry (2DLC-MS/MS) approaches using a hybrid quadrupole time-of-flight system (QqTOF). The study resulted in the reproducible identification of 825 nonredundant gene products (p = 2-fold) and another 35 exhibited downregulation ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
