| Autor: |
Sgouros, D. Lallas, A. Kittler, H. Zarras, A. Kyrgidis, A. Papageorgiou, C. Puig, S. Scope, A. Argenziano, G. Zalaudek, I. Pizzichetta, M.A. Marghoob, A. Liopyris, K. Malvehy, J. Oikonomou, C. Flórez, A. Braun, R. Cabo, H. Nazzaro, G. Lanssens, S. Menzies, S. Paoli, J. Kaminska – Winciorek, G. Longo, C. Katoulis, A. Apalla, Z. Ioannides, D. Thomas, L. Tromme, I. Ogata, D. Desinioti, C. Geller, A. Stratigos, A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Popis: |
Background: Thin nodular melanoma (NM) often lacks conspicuous melanoma-specific dermatoscopic criteria and escapes clinical detection until it progresses to a thicker and more advanced tumour. Objective: To investigate the dermatoscopic morphology of thin (≤2 mm Breslow thickness) vs. thick (>2 mm) NM and to identify dermatoscopic predictors of its differential diagnosis from other nodular tumours. Methods: Retrospective, morphological case–control study, conducted on behalf of the International Dermoscopy Society. Dermatoscopic images of NM and other nodular tumours from 19 skin cancer centres worldwide were collected and analysed. Results: Overall, 254 tumours were collected (69 NM of Breslow thickness ≤2 mm, 96 NM >2 mm and 89 non-melanoma nodular lesions). Light brown coloration (50.7%) and irregular brown dots/globules (42.0%) were most frequently observed in ≤2 mm NMs. Multivariate analysis revealed that dotted vessels (3.4-fold), white shiny streaks (2.9-fold) and irregular blue structureless area (2.4-fold) were predictors for thinner NM compared to non-melanoma nodular tumours. Overall, irregular blue structureless area (3.4-fold), dotted vessels (4.6-fold) and serpentine vessels (1.9-fold) were predictors of all NM compared to non-melanoma nodular lesions. Limitations: Absence of a centralized, consensus pathology review and cases selected form tertiary centres maybe not reflecting the broader community. Conclusions: Our study sheds light into the dermatoscopic morphology of thin NM in comparison to thicker NM and could provide useful clues for its differential diagnosis from other non-melanoma nodular tumours. © 2020 European Academy of Dermatology and Venereology |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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