| Autor: |
Nanas, JN Papazoglou, PP Terrovitis, JV Kanakakis, J and Dalianis, A Tsolakis, E Tsagalou, EP Agrios, N and Christodoulou, K Anastasiou-Nana, MI |
| Jazyk: |
angličtina |
| Rok vydání: |
2004 |
| Popis: |
A 24-hour infusion of levosimendan was added to dobutamine in 18 patients (aged 63 +/- 9 years) hospitalized for management of decompensated New York Heart Association functional class IV heart failure refractory to a continuous 24-hour infusion of dobutamine (10 mug/kg/min) and furosemide (10 mg/hour); the primary study end point was a greater than or equal to40% increase in cardiac index and a greater than or equal to25% decrease in pulmonary capillary wedge pressure compared with pretreatment measurements. The primary end point was reached in none of the patients treated with dobutamine alone versus 7 patients (39%) treated with levosimendan and dobutamine combined (p = 0.008), whereas at 24 hours, the combined treatment was associated with a 0.76 +/- 0.78 L/min/m(2) (p = 0.001) mean increase in cardiac index and a 6.4 +/- 7.3 mm Hg (p = 0.002) mean decrease in pulmonary capillary wedge pressure compared with measurements obtained after 24 hours of dobutamine infusion alone. Symptoms were alleviated in, all patients, and all but 3 were discharged from the hospital. (C) 2004 by Excerpta Medica, Inc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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