Successful trovafloxacin prophylaxis against experimental streptococcal aortic valve endocarditis
| Autor: | Katsarolis, I Pefanis, A Iliopoulos, D Siaperas, P and Karayiannakos, P Giamarellou, H |
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| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: | |
| Popis: | Single-dose trovafloxacin (15 mg/kg given intravenously [i.v.]) and ampicillin (40 mg/kg given i.v.) protected 38 and 33% of animals challenged with an ampicillin-tolerant strain of Streptococcus oralis, respectively. As a double-dose regimen, trovafloxacin afforded total protection (100%; P < 0.001 versus controls). Trovafloxacin is the first fluoroquinolone effective in preventing experimental streptococcal endocarditis. |
| Databáze: | OpenAIRE |
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