| Autor: |
Kalogeropoulos, D. Papoudou-Bai, A. Lane, M. Goussia, A. Charchanti, A. Moschos, M.M. Kanavaros, P. Kalogeropoulos, C. |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Purpose: To review the role of antigen-presenting cells (APC) in the pathogenesis of ocular surface diseases (OSD). Methods: A thorough literature search was performed in PubMed database. An additional search was made in Google Scholar to complete the collected items. Results: APCs have the ability to initiate and direct immune responses and are found in most lymphoid and non-lymphoid tissues. APCs continuously sample their environment, present antigens to T cells and co-ordinate immune tolerance and responses. Many different types of APCs have been described and there is growing evidence that these cells are involved in the pathogenesis of OSD. OSD is a complex term for a myriad of disorders that are often characterized by ocular surface inflammation, tear film instability and impairment of vision. Conclusions: This review summarizes the current knowledge concerning the immunotopographical distribution of APCs in the normal ocular surface. APCs appear to play a critical role in the pathology of a number of conditions associated with OSD including infectious keratitis, ocular allergy, dry eye disease and pterygium. © 2020, Springer Nature B.V. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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