| Autor: |
Vineis, P. Veglia, F. Garte, S. Malaveille, C. Matullo, G. Dunning, A. Peluso, M. Airoldi, L. Overvad, K. Raaschou-Nielsen, O. Clavel-Chapelon, F. Linseisen, J.P. Kaaks, R. Boeing, H. Trichopoulou, A. Palli, D. Crosignani, P. Tumino, R. Panico, S. Bueno-De-Mesquita, H.B. Peeters, P.H. Lund, E. Gonzalez, C.A. Martinez, C. Dorronsoro, M. Barricarte, A. Navarro, C. Quiros, J.R. Berglund, G. Jarvholm, B. Day, N.E. Key, T.J. Saracci, R. Riboli, E. Autrup, H. |
| Jazyk: |
angličtina |
| Rok vydání: |
2007 |
| Popis: |
Background: We chose a set of candidate single nucleotide polymorphisms (SNPs) to investigate gene-environment interactions in three types of cancer that have been related to air pollution (lung, bladder and myeloid leukemia). Patients and methods: The study has been conducted as a nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort (409 cancer cases and 757 matched controls). We included never and ex-smokers. SNPs were in genes involved in oxidative stress, phase I metabolizing genes, phase II metabolizing genes and methylenetetrahydrofolate reductase (MTHFR). Results: The most notable findings are: GSTM1 deletion and bladder cancer risk [odds ratio (OR) = 1.60; 95% confidence interval 1.00-2.56]; CYP1A1 and leukemia (2.22, 1.33-3.70; heterozygotes); CYP1B1 and leukemia (0.47, 0.27-0.84; homozygotes); MnSOD and leukemia (1.91, 1.08-3.38; homozygotes) and NQO1 and lung cancer (8.03, 1.73-37.3; homozygotes). Other statistically significant associations were found in subgroups defined by smoking habits (never or ex-smokers), environmental tobacco smoke or gender, with no obvious pattern. When gene variants were organized according to the three main pathways, the emerging picture was of a strong involvement of combined phase I enzymes in leukemia, with an OR of 5 (1.63-15.4) for those having three or more variant alleles. The association was considerably stronger for leukemias arising before the age of 55. © 2007 European Society for Medical Oncology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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