| Autor: |
Giannitsioti, E. Pefanis, A. Gogos, C. Lekkou, A. Dalekos, G.N. Gatselis, N. Georgiadou, S. Nikou, P. Vrettou, A. Rigopoulos, A. Tryfonopoulos, C. Tsaganos, T. Karofilakis, E. Psarrakis, C. Argyriou, M. Gargalianos-Kakolyris, P. Adamis, G. Lourida, P. Kofteridis, D. Andrianaki, A. Loupa, C. Kostis, E. Sinapidis, D. Sympardi, S. Alexiou, N. Karaiskos, I. Masgala, A. Maltezos, E. Panagopoulos, P. Sachpekidis, V. Evdoridis, C. Sipsas, N.V. Daikos, G. Giamarellou, H. Pontikis, K. Lioris, I. Lelekis, M. Trikkas, A. Aggouras, D. Kolias, V. Rokkas, C. Nana-Anastasiou, M. Miyakis, S. On behalf of the Hellenic Society of Chemotherapy |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Popis: |
Objective: The clinical profile, management and outcome of infective endocarditis (IE) may be influenced by socioeconomic issues. Methods: A nationwide prospective study evaluated IE during the era of deep economic crisis in Greece. Epidemiological data and factors associated with 60-day mortality were analyzed through descriptive statistics, logistic and Cox-regression models. Results: Among 224 patients (male 72.3%, mean age 62.4 years), Staphylococcus aureus (n = 62; methicillin-resistant S. aureus (MRSA) 33.8%) predominated in the young without impact on mortality (p = 0.593), whilst Enterococci (n = 36) predominated in the elderly. Complications of IE were associated with mortality: heart failure [OR 2.415 (95% CI: 1.159–5.029), p = 0.019], stroke [OR 3.206 (95% CI: 1.190–8.632), p = 0.018] and acute kidney injury [OR 2.283 (95% CI: 1.085–4.805), p = 0.029]. A 60-day survival benefit was solely related to cardiac surgery for IE during hospitalization [HR 0.386 (95% CI: 0.165–0.903), p = 0.028] and compliance with antimicrobial treatment guidelines [HR 0.487 (95% CI: 0.259–0.916), p = 0.026]. Compared with a previous country cohort study, history of rheumatic fever and native valve predisposition had declined, whilst underlying renal disease and right-sided IE had increased (p < 0.0001); HIV infection had emerged (p = 0.002). No difference in rates of surgery and outcome was assessed. Conclusions: A country-wide survey of IE highlighted emergence of HIV, right-sided IE and predominance of MRSA in the youth during a severe socioeconomic crisis. Compliance with treatment guidelines promoted survival. © 2021 The Authors |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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