| Autor: |
Papageorgiou, Nikolaos Briasoulis, Alexandros Hatzis, Georgios and Androulakis, Emmanuel Kozanitou, Maria Miliou, Antigoni and Charakida, Marietta Zacharia, Effimia Papaioannou, Spyridon and Paroutoglou, Ioannis Siasos, Gerasimos Pallantza, Zoi and Tousoulis, Dimitris |
| Rok vydání: |
2017 |
| Popis: |
Introduction and objectives: We examined whether the rs180070 and rs2070011 polymorphisms of the fibrinogen gene could affect the risk of coronary artery disease in hypertensive patients by modifying the inflammatory process and coagulation. Methods: A total of 744 participants underwent coronary angiography due to symptoms of stable angina, while hypertension was present in 332 patients. Results: The presence of the A allele (rs180070) was associated with significantly high levels of fibrinogen in hypertensive patients (P =.05). On multivariate analysis, A homozygosity (rs180070) (b = 0.257 +/- 18.6; P 443 mg/dL (odds ratio = 3.50; 95% confidence interval, 1.14-10.90; P =.029), but not A homozygosity (odds ratio = 3.00; 95% confidence interval, 0.78-11.90; P =.110) were independent predictors of the presence of coronary artery disease. Moreover, interleukin-6 levels were higher in A homozygotes for the rs180070 polymorphism compared with all other genotypes (P =.046). Indeed, this genotype was the only adjusted independent predictor of interleukin- 6 levels (beta = 0.151 +/- 0.642; P =.032). It was also associated with higher D-dimer levels in hypertension compared with G allele carriers (P =.048). Conclusions: The presence of A homozygosity (rs180070) is associated with increased levels of inflammatory mediators and a higher incidence of angiographic coronary artery disease. Importantly, fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients. Full English text available from: www.revespcardiol.org/en (C) 2016 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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