| Autor: |
Shen, L. Kapsogeorgou, E.K. Yu, M. Suresh, L. Malyavantham, K. Tzioufas, A.G. Ambrus, J.L. |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Popis: |
Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS.The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS.The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La.In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome. © 2014 Elsevier Inc. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
