| Popis: |
A novel two step methodology for readily accessible natural “pulvinone” derivatives in excellent yields has been developed starting from activated precursors, bearing a functionalized 1,3-dioxolane-2,4-diones (OCA’s), as dually protected-activated synthons of α-hydroxy acids. The present procedure is based on a tandem C-acylation-cyclization process under mild conditions with good yields. Additionally, pulvinones show an important medicinal profile with the tetronate heterocycle exhibiting favorable pharmacokinetic (PK) and ADME-Tox properties that can be considered unexploited so far due to synthetic limitations. © 2021 Taylor & Francis Group, LLC. |
