| Autor: |
Balk, M., Behl, M., Nöchel, U., Lendlein, A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Zdroj: |
Balk, M.; Behl, M.; Nöchel, U.; Lendlein, A.: Enzymatically Triggered Jack-in-the-Box-like Hydrogels. In: ACS Applied Materials and Interfaces. Vol. 13 (2021) 7, 8095-8101. (DOI: /10.1021/acsami.1c00466) |
| ISSN: |
1944-8244 |
| Popis: |
Enzymes can support the synthesis or degradation of biomacromolecules in natural processes. Here, we demonstrate that enzymes can induce a macroscopic-directed movement of microstructured hydrogels following a mechanism that we call a “Jack-in-the-box” effect. The material’s design is based on the formation of internal stresses induced by a deformation load on an architectured microscale, which are kinetically frozen by the generation of polyester locking domains, similar to a Jack-in-the-box toy (i.e., a compressed spring stabilized by a closed box lid). To induce the controlled macroscopic movement, the locking domains are equipped with enzyme-specific cleavable bonds (i.e., a box with a lock and key system). As a result of enzymatic reaction, a transformed shape is achieved by the release of internal stresses. There is an increase in entropy in combination with a swelling-supported stretching of polymer chains within the microarchitectured hydrogel (i.e., the encased clown pops-up with a pre-stressed movement when the box is unlocked). This utilization of an enzyme as a physiological stimulus may offer new approaches to create interactive and enzyme-specific materials for different applications such as an optical indicator of the enzyme’s presence or actuators and sensors in biotechnology and in fermentation processes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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