Effet de l'inhibition spécifique de la réplication de l'ADN par l'aphidicoline sur la différenciation primaire de l'auf de souris en préimplantation
| Autor: | Alexandre, Henri |
|---|---|
| Jazyk: | francouzština |
| Rok vydání: | 1982 |
| Předmět: |
Génétique du développement
animal structures DNA Replication -- drug effects Blastocyst -- drug effects -- physiology DNA Polymerase II -- antagonists & inhibitors Mice Aphidicolin Cell Differentiation -- drug effects embryonic structures Animals Female Cell Cycle -- drug effects Diterpenes -- pharmacology Nucleic Acid Synthesis Inhibitors |
| Zdroj: | Comptes rendus des séances de l'Académie des sciences. Série III, Sciences de la vie, 294 (21 |
| Popis: | Aphidicolin inhibits cleavage at every stage of preimplantation of Mouse embryos without affecting compaction. Blastulation is initiated only if the treatment is applied at the late 8-cell stage. It is concluded that the S phase of the 4th cell cycle might be critical for the commitment of the embryo for blastocyst formation. The 4th cycle thus corresponds to a "quantal cell cycle". Moreover, aphidicolin induces premature cavitation which occurs even when the embryos have not yet initiated cytokinesis. info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|