Sequential high-dose methotrexate and fluorouracil combined with doxorubicin: A step ahead in the treatment of advanced gastric cancer: a trial of the European organization for research and treatment of cancer gastrointestinal tract cooperative group
| Autor: | Wils, Jaques, Klein, Hans Otto, Wagener, Th, Bleiberg, Harry, Reis, Hans Edgar H., Korsten, Friedrich Wilhelm F., Conroy, Thierry, Fickers, Martin M F M., Leyvraz, Serge, Buyse, Marc, Duez, Nicole |
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| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: | |
| Zdroj: | Journal of clinical oncology, 9 (5 |
| Popis: | In a prospective phase III multicenter trial, 213 patients with advanced measurable or nonmeasurable gastric cancer were randomized to receive methotrexate (MIX), fluorouracil (5-FU), and Adriamycin (doxorubicin; Farmitalia Carlo Erba, Milan, Italy) (FAMTX) or 5-FU, Adriamycin, and mitomycin (FAM). The results show a significantly superior response rate (41% v 9% [P < .0001]), and survival (median, 42 weeks v 29 weeks [P = .004]) for FAMTX. There was a cumulative thrombocytopenia in FAM and not in FAMTX. The FAMTX protocol should be the reference treatment in future clinical trials that seek to improve the therapeutic outcome in advanced gastric cancer. © 1991 by American Society of Clinical Oncology. SCOPUS: ar.j info:eu-repo/semantics/published |
| Databáze: | OpenAIRE |
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