| Autor: |
De Vos, Ann, Jacobs, Dirk, Struyfs, Hanne, Fransen, Erik, Andersson, Kerstin, Portelius, Erik, Andreasson, Ulf, De Surgeloose, Didier, Hernalsteen, Danielle, Sleegers, Kristel, Robberecht, Caroline, Van Broeckhoven, Christine, Zetterberg, Henrik, Blennow, Kaj, Engelborghs, Sebastiaan, Vanmechelen, Eugeen |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Alzheimer's & dementia |
| ISSN: |
1552-5260 |
| Popis: |
Background: Biomarkers monitoring synaptic degeneration/loss would be valuable for Alzheimers disease (AD) diagnosis. Post-synaptic protein neurogranin may be a promising CSF biomarker but has not yet been evaluated as plasma biomarker. Methods: Using an in-house designed prototype ELISA targeting neurogranin C-terminally, we studied neurogranin in paired CSF/plasma samples of controls (n=29) versus patients experiencing MCI, or dementia, due to AD (in total n=59). Results: CSF neurogranin was increased in AD and positively correlated with CSF tau while there was a negative relationship between CSF neurogranin (and tau) and CSF Aβ1-42/Aβ1-40. No differences were detected in plasma neurogranin between controls and AD. Also, there was no correlation between CSF and plasma neurogranin, excluding confounding effects of the latter. Conclusions: This study strengthens the potential of neurogranin as an AD CSF biomarker, which now needs validation in larger studies. As tools, straightforward immuno-assays can be used, as demonstrated by the described ELISA. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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