| Autor: |
Selleslag, D., Dierickx, D., Breems, D.A., Huynh, P., Van de Velde, Ann, Meers, S., Brouwer, E., Mertens, A. |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Acta clinica Belgica |
| ISSN: |
0001-5512 |
| Popis: |
Introduction: Currently available stem cell mobilizing regimens (G-CSF +/- chemotherapy) show high failure rates, especially in heavily pretreated patients. Plerixafor, a new stem cell mobilizing agent blocking the CXCR4-SDF-1 interaction, offers a new strategy for stem cell mobilization, especially in poor mobilizers. This study reports on the outcome of the Belgian compassionate use program (CUP). Materials and methods: Between July 2008 and July 2009, 14 Belgian transplant centres participated in plerixafor CUR In total, 22 poor stem cell mobilizers were included. Patients who previously failed stem cell mobilization received a combination of G-CSF (morning of Day 1-5) and plerixafor (evening of Day 4). Apheresis was performed on Day 5. G-CSF, plerixafor and apheresis were continued until at least 2 x 10(6)/kg CD34+ cells were obtained in a maximum of 3 collections. Results: A mean of 2 plerixafor administrations was needed to reach >= 2 x 10(6)/kg CD34+ cells. The overall cumulative success rate (defined as the proportion of patients achieving a successful collection after a maximum of 3 apheresis days) was 64%. Half of the heavily pretreated patients (>= 3 prior chemotherapy regimens) could be mobilized successfully. Patients who received = 3 prior chemotherapy regimens. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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