BAFF, APRIL and their receptors: structure, function and signaling

Autor: Bossen, C., Schneider, P.
Jazyk: angličtina
Rok vydání: 2006
Předmět:
stomatognathic diseases
stomatognathic system
immune system diseases
Alternative Splicing
Animals
Antigen Presentation/physiology
Apoptosis/physiology
B-Cell Activating Factor/chemistry
B-Cell Activating Factor/genetics
B-Cell Activation Factor Receptor/chemistry
B-Cell Activation Factor Receptor/genetics
B-Cell Maturation Antigen/physiology
B-Lymphocytes/cytology
B-Lymphocytes/immunology
Humans
Immunoglobulin Class Switching/physiology
Lymphocyte Activation
Lymphocyte Subsets/immunology
Mice
Models
Molecular
NF-kappa B/physiology
NF-kappa B p50 Subunit/physiology
Protein Conformation
Protein Interaction Mapping
Protein Kinase C-delta/antagonists & inhibitors
Signal Transduction
Structure-Activity Relationship
Substrate Specificity
Transmembrane Activator and CAML Interactor Protein/chemistry
Transmembrane Activator and CAML Interactor Protein/genetics
Tumor Necrosis Factor Ligand Superfamily Member 13/chemistry
Tumor Necrosis Factor Ligand Superfamily Member 13/genetics
Zdroj: Seminars in Immunology, vol. 18, no. 5, pp. 263-275
Popis: BAFF, APRIL and their receptors play important immunological roles, especially in the B cell arm of the immune system. A number of splice isoforms have been described for both ligands and receptors in this subfamily, some of which are conserved between mouse and human, while others are species-specific. Structural and mutational analyses have revealed key determinants of receptor-ligand specificity. BAFF-R has a strong selectivity for BAFF; BCMA has a higher affinity for APRIL than for BAFF, while TACI binds both ligands equally well. The molecular signaling events downstream of BAFF-R, BCMA and TACI are still incompletely characterized. Survival appears to be mediated by upregulation of Bcl-2 family members through NF-kappaB activation, degradation of the pro-apototic Bim protein, and control of subcellular localization of PCKdelta. Very little is known about other signaling events associated with receptor engagement by BAFF and APRIL that lead for example to B cell activation or to CD40L-independent Ig switch.
Databáze: OpenAIRE
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