Association between confirmed congenital Zika infection at birth and outcomes up to 3 years of life
| Autor: | Hcini, N., Kugbe, Y., Rafalimanana, ZHL, Lambert, V., Mathieu, M., Carles, G., Baud, D., Panchaud, A., Pomar, L. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adolescent
Adult Child Development Child Preschool Female French Guiana/epidemiology Humans Infant Infant Newborn Male Maternal Age Nervous System Malformations/epidemiology Nervous System Malformations/etiology Pregnancy Pregnancy Complications Infectious/diagnosis Pregnancy Complications Infectious/virology Prenatal Exposure Delayed Effects/epidemiology Prenatal Exposure Delayed Effects/etiology Risk Assessment/statistics & numerical data Young Adult Zika Virus/isolation & purification Zika Virus Infection/complications Zika Virus Infection/congenital Zika Virus Infection/diagnosis Zika Virus Infection/virology |
| Zdroj: | Nature communications, vol. 12, no. 1, pp. 3270 |
| Popis: | Little is known about the long-term neurological development of children diagnosed with congenital Zika infection at birth. Here, we report the imaging and clinical outcomes up to three years of life of a cohort of 129 children exposed to Zika virus in utero. Eighteen of them (14%) had a laboratory confirmed congenital Zika infection at birth. Infected neonates have a higher risk of adverse neonatal and early infantile outcomes (death, structural brain anomalies or neurologic symptoms) than those who tested negative: 8/18 (44%) vs 4/111 (4%), aRR 10.1 [3.5-29.0]. Neurological impairment, neurosensory alterations or delays in motor acquisition are more common in infants with a congenital Zika infection at birth: 6/15 (40%) vs 5/96 (5%), aRR 6.7 [2.2-20.0]. Finally, infected children also have an increased risk of subspecialty referral for suspected neurodevelopmental delay by three years of life: 7/11 (64%) vs 7/51 (14%), aRR 4.4 [1.9-10.1]. Infected infants without structural brain anomalies also appear to have an increased risk, although to a lesser extent, of neurological abnormalities. It seems paramount to offer systematic testing for congenital ZIKV infection in cases of in utero exposure and adapt counseling based on these results. |
| Databáze: | OpenAIRE |
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