I(nsp1)ecting SARS-CoV-2-ribosome interactions
| Autor: | Simeoni, M., Cavinato, T., Rodriguez, D., Gatfield, D. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
5' Untranslated Regions
Gene Expression Regulation Viral Host-Pathogen Interactions/physiology Humans Immunity Innate Protein Biosynthesis RNA Messenger/metabolism Ribosomes/metabolism Ribosomes/virology SARS-CoV-2/genetics SARS-CoV-2/pathogenicity Viral Nonstructural Proteins/chemistry Viral Nonstructural Proteins/genetics Viral Nonstructural Proteins/metabolism viruses virus diseases |
| Zdroj: | Communications biology, vol. 4, no. 1, pp. 715 |
| Popis: | While SARS-CoV-2 is causing modern human history's most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), binds human ribosomes to inhibit host cell translation. Here, we examine the main conclusions on the molecular activity of Nsp1 and its role in suppressing innate immune responses. We discuss different scenarios potentially explaining how the viral RNA can bypass its own translation blockage and speculate on the suitability of Nsp1 as a therapeutic target. |
| Databáze: | OpenAIRE |
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