| Autor: |
Bianchetti, D., Salvador Nunes, L., André, P., Schoepfer, A., Moradpour, D., Chtioui, H. |
| Jazyk: |
francouzština |
| Rok vydání: |
2022 |
| Zdroj: |
Revue medicale suisse, vol. 18, no. 793, pp. 1588-1593 |
| Popis: |
Azathioprine keeps an important place in the treatment of inflammatory bowel disease and autoimmune hepatitis. This molecule has a narrow therapeutic margin, associated with a risk of toxicity, particularly hematological and hepatic. Its complex metabolism is subject to genetic polymorphisms that are reflected in the inter-individual variability observed in the response to treatment and its tolerance profile. Hence, its use requires a good knowledge of this molecule. Treatment is initiated after a preliminary workup, followed by a progressive titration of the dosage while closely monitoring possible toxicities. Monitoring of blood levels of metabolites (including active ones) helps guide personalized dose adjustment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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