The multifaceted role of cell cycle regulators in the coordination of growth and metabolism
| Autor: | Huber, K., Mestres-Arenas, A., Fajas, L., Leal-Esteban, L.C. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adaptation
Physiological Animals Cell Cycle/drug effects Cell Cycle/genetics Cells Cultured Cyclin-Dependent Kinase Inhibitor Proteins/genetics Cyclin-Dependent Kinase Inhibitor Proteins/metabolism Cyclin-Dependent Kinases/antagonists & inhibitors Cyclin-Dependent Kinases/genetics Cyclin-Dependent Kinases/metabolism Cyclins/genetics Cyclins/metabolism E2F Transcription Factors/genetics E2F Transcription Factors/metabolism Endosomes/drug effects Endosomes/metabolism Gene Expression Regulation Humans Lysosomes/drug effects Lysosomes/metabolism Mitochondria/drug effects Mitochondria/metabolism Nutritive Value/physiology Protein Kinase Inhibitors/pharmacology Retinoblastoma Protein/genetics Retinoblastoma Protein/metabolism Saccharomyces cerevisiae/drug effects Saccharomyces cerevisiae/growth & development Saccharomyces cerevisiae/metabolism Signal Transduction cell cycle regulators cell growth endolysosomes metabolism mitochondria |
| Zdroj: | The FEBS journal, vol. 288, no. 12, pp. 3813-3833 |
| Popis: | Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires a multi-directional coordination between metabolism, growth, and the cell cycle regulators (consisting of the family of cyclin-dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, the retinoblastoma family members, and the E2F transcription factors). Deciphering the mechanisms accountable for this coordination is crucial for understanding various patho-physiological processes. While it is well established that metabolism and growth affect cell division, this review will focus on recent observations that demonstrate how cell cycle regulators coordinate metabolism, cell cycle progression, and growth. We will discuss how the cell cycle regulators directly regulate metabolic enzymes and pathways and summarize their involvement in the endolysosomal pathway and in the functions and dynamics of mitochondria. |
| Databáze: | OpenAIRE |
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