Re-education of macrophages as a therapeutic strategy in cancer
| Autor: | Kowal, J., Kornete, M., Joyce, J.A. |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
stomatognathic system
Animals Humans Immunotherapy Macrophages/immunology Macrophages/pathology Neoplasms/immunology Neoplasms/pathology Neoplasms/therapy Tumor Microenvironment/immunology anticancer treatment cancer immunotherapy macrophages tumor microenvironment tumor-associated macrophages skin and connective tissue diseases hormones hormone substitutes and hormone antagonists |
| Zdroj: | Immunotherapy, vol. 11, no. 8, pp. 677-689 |
| Popis: | Tumor-associated macrophages (TAMs) can be educated within the tumor microenvironment to promote cancer development and progression. While TAM-targeted agents have largely focused on macrophage depletion as an anticancer strategy, it is becoming increasingly evident that TAM re-education may represent a more effective approach. In this perspective, we discuss different means to achieve TAM re-education, and review the beneficial effects of these strategies, particularly when combined with immune checkpoint inhibitors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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