Psychiatric disorders in children with 16p11.2 deletion and duplication
| Autor: | Niarchou, M., Chawner, SJRA, Doherty, J.L., Maillard, A.M., Jacquemont, S., Chung, W.K., Green-Snyder, L., Bernier, R.A., Goin-Kochel, R.P., Hanson, E., Linden, DEJ, Linden, S.C., Raymond, F.L., Skuse, D., Hall, J., Owen, M.J., Bree, MBMVD |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adolescent
Attention Deficit Disorder with Hyperactivity/diagnosis Attention Deficit Disorder with Hyperactivity/genetics Autism Spectrum Disorder/diagnosis Autism Spectrum Disorder/genetics Case-Control Studies Child Child Preschool Chromosome Duplication Chromosomes Human Pair 16/genetics DNA Copy Number Variations Female Heterozygote Humans Male Sequence Deletion |
| Zdroj: | Translational psychiatry, vol. 9, no. 1, pp. 8 |
| Popis: | Deletion and duplication of 16p11.2 (BP4-BP5) have been associated with an increased risk of intellectual disability and psychiatric disorder. This is the first study to compare the frequency of a broad spectrum of psychiatric disorders in children with 16p11.2 deletion and duplication. We aimed to evaluate (1) the nature and prevalence of psychopathology associated with copy number variation (CNV) in children with 16p11.2 by comparing deletion and duplication carriers with family controls; (2) whether deletion and duplication carriers differ in frequency of psychopathology. 217 deletion carriers, 77 deletion family controls, 114 duplication carriers, and 32 duplication family controls participated in the study. Measures included standardized research diagnostic instruments. Deletion carriers had a higher frequency of any psychiatric disorder (OR = 8.9, p |
| Databáze: | OpenAIRE |
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