Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon
| Autor: | Mylonas, A., Conrad, C. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Humans
Immunologic Memory Interferon Type I/immunology Interleukin-23/immunology Psoriasis/immunology Psoriasis/pathology Signal Transduction/immunology Th17 Cells/immunology Th17 Cells/pathology Tumor Necrosis Factor-alpha/immunology IL-23 TH17 TNF paradoxical psoriasis plaque psoriasis type I-interferon |
| Zdroj: | Frontiers in immunology, vol. 9, pp. 2746 |
| Popis: | Chronic plaque psoriasis is a common debilitating skin disease. The identification of the pathogenic role of the TNF/IL-23/T H 17 pathway has enabled the development of targeted therapies used in the clinic today. Particularly, TNF inhibitors have become a benchmark for the treatment of numerous chronic inflammatory diseases such as psoriasis. Although being highly effective in psoriasis treatment, anti-TNFs can themselves induce psoriasis-like skin lesions, a side effect called paradoxical psoriasis. In this review, we provide a comprehensive look at the different cellular and molecular players involved in classical plaque psoriasis and contrast its pathogenesis to paradoxical psoriasis, which is clinically similar but immunologically distinct. Classical psoriasis is a T-cell mediated autoimmune disease driven by TNF, characterised by T-cells memory, and a relapsing disease course. In contrast, paradoxical psoriasis is caused by the absence of TNF and represents an ongoing type-I interferon-driven innate inflammation that fails to elicit T-cell autoimmunity and lacks memory T cell-mediated relapses. |
| Databáze: | OpenAIRE |
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