Seasonal influenza vaccination: prioritizing children or other target groups? : Part II: cost-effectiveness analysis
| Autor: | Beutels, Philippe |
|---|---|
| Přispěvatelé: | Vandendijck, Yannick, Willem, Lander, Goeyvaerts, Nele, Blommaert, Adriaan, van Kerckhove, Kim, Bilcke, J, Hanquet, Germaine, Neels, P., Thiry, Nancy, Liesenborgs, Jori, Hens, Niel |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Popis: | 247 p. Ill. SCIENTIFIC REPORT 16 -- 1 BACKGROUND 16 -- 2 OBJECTIVES 18 -- 3 EVIDENCE REVIEWS 18 -- 3.1 VACCINE EFFICACY AND EFFECTIVENESS 18 -- 3.1.1 Methods 18 -- 3.1.2 Influenza vaccine efficacy in children. 20 -- 3.1.3 Influenza vaccine efficacy in healthy adults 25 -- 3.1.4 Influenza vaccine efficacy/effectiveness in the elderly 26 -- 3.1.5 Influenza vaccine efficacy/effectiveness in the persons ≤65 years with co-morbidities 29 -- 3.2 VACCINE SAFETY 30 -- 3.2.1 Influenza vaccines safety in children 30 -- 3.2.2 Influenza vaccines safety in adults 31 -- 3.2.3 Special potential issues for influenza vaccine safety 33 -- 3.3 ECONOMIC EVALUATIONS 34 -- 3.3.1 Childhood vaccination options 34 -- 3.3.2 Adult vaccination options 40 -- 3.4 DYNAMIC TRANSMISSION MODELS 44 -- 3.4.1 Search strategy 44 -- 3.4.2 Results 45 -- 3.5 QUALITY OF LIFE 54 -- 3.5.1 Search strategy 54 -- 3.5.2 Results 54 -- 4 DATA COLLECTION AND INTERMEDIARY ANALYSES 59 -- 4.1 EPIDEMIOLOGICAL AND BURDEN OF DISEASE DATA 59 -- 4.1.1 ILI and influenza surveillance, hospitalization rates and deaths 59 -- 4.1.2 Estimation of influenza related admissions and deaths through regression analyses 59 -- 4.2 COST DATA 65 -- 4.2.1 Out of hospital costs for Influenza Like Illness (ILI) and clinically diagnosed influenza 65 -- 4.2.2 In-hospital costs for hospitalised influenza patients 76 -- 5 METHODS 80 -- 5.1 OPTIONS FOR VACCINATION 80 -- 5.1.1 Using the dynamic transmission model 80 -- 5.1.2 Using the static models 81 -- 5.2 DESCRIPTION OF THE DYNAMIC TRANSMISSION MODEL 81 -- 5.2.1 Model structure 81 -- 5.2.2 Fundamental differences between our and Vynnycky et al’s approach 87 -- 5.2.3 Dynamic model parameter imputation by fitting to past observations 89 -- 5.3 DESCRIPTION OF THE STATIC MODELS 97 -- 5.4 ANALYTICAL APPROACH TO ECONOMIC EVALUATION 97 -- 5.5 PARAMETER VALUES AND DISTRIBUTIONS 99 -- 5.5.1 Parameters for dynamic transmission model-based projections 99 -- 5.5.2 Parameters for static model-based projections 105 -- 6 RESULTS 119 -- 6.1 OPTIONS CONSIDERED WITH THE DYNAMIC TRANSMISSION MODEL 119 -- 6.1.1 Modified children options + current adult vaccination 119 -- 6.1.2 Current children vaccination + modified adult vaccination targets 132 -- 6.1.3 Modified children options + modified adult vaccination targets 140 -- 6.1.4 Modified children options + modified adult vaccination reduction 156 -- 6.1.5 Sensitivity analyses 166 -- 6.2 OPTIONS CONSIDERED WITH THE STATIC MODELS 208 -- 6.2.1 Vaccinating pregnant women 208 -- 6.2.2 Vaccinating health care workers (HCWs) 212 -- 6.2.3 Vaccinating people with comorbidities 220 -- 7 SUMMARY AND DISCUSSION 225 -- 7.1 VACCINATING CHILDREN 225 -- 7.2 CHANGING COVERAGE IN ADULTS WITH OR WITHOUT CHILDHOOD VACCINATION 227 -- 7.3 LIMITATIONS OF THE STUDY 227 -- 7.4 FUTURE PERSPECTIVES 228 -- REFERENCES 230 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|