BMPR2 acts as a gatekeeper to protect endothelial cells from increased TGFβ responses and altered cell mechanics

Autor: Hiepen, C., Jatzlau, J., Hildebrandt, S., Kampfrath, B., Göktas, M., Murgai, A., Camacho, C., Luis, J., Haag, R., Ruppert, C., Sengle, G., Cavalcanti-Adam, E., Blank, K., Knaus, P.
Jazyk: angličtina
Rok vydání: 2019
Zdroj: PLoS Biology
Popis: Balanced TGFβ/BMP-signaling is essential for tissue formation and homeostasis; this study shows that the receptor BMPR2 serves as gatekeeper of this balance, protecting cells from increased TGFβ-responses and integrin-mediated mechanotransduction.
Databáze: OpenAIRE