| Autor: |
Neyer, Sabrina E., Witthöft, Michael, Cropley, Mark, Pawelzik, Markus, Sütterlin, Stefan, Lugo, Ricardo Gregorio |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Neuroscience |
| Popis: |
The cortisol awakening response is a non-invasive biomarker for hypothalamic-pituitary-adrenal axis (HPA) dysregulation, reflecting accumulated stress over time. In a previous study we reported that a blunted CAR before an inpatient treatment predicted self-reported depressive symptoms six weeks and six months after discharge (XXXXXXXXX et al., 2019). This replication study adopted an improved overall methodology with more stringent assessment protocols and monitoring. The longitudinal design included 122 inpatients from a psychosomatic hospital with a diagnosis of Major Depression Disorder displaying symptoms of moderate to severe major depression (n=80 females). The Cortisol awakening response (CAR) was measured at intake. Depression severity was assessed as Beck Depression Inventory II scores at intake, discharge, six weeks and six months following discharge. Results from the original study were replicated in terms of effect size but did not reach statistical significance (correlation between BDI-II 6 months after discharge and AUCg: r=-.213; p=.054). The replication study yielded nearly identical correlation coefficients as in the original study (BDI-II 6 months and CAR, r=-.223, p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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