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Background: Chronic hepatitis C virus genotype 1 (HCV-G1) infection is treated with pegylated interferon- and ribavi- rin. Predictive factors for treatment success are even more important now as direct-acting antiviral agents are available. Methods: Clinical and laboratory parameters were analyzed by uni- and multivariate statistical means in 264 patients with HCV-G1 infections with regard to treatment outcome. Results: The overall sustained virological response (SVR) rate was 44%. Univariate analyses revealed SVRs to be associated with age, high alanine aminotransferase (ALT) and low -glu- tamyltransferase ( -GT) serum activities, a low pretreatment -GT/ALT ratio, rapid virological response (RVR), and absence of steatosis. Multivariate analyses unveiled IL28B rs12979860 genotype (CC vs. CT: OR = 2.8, CI: 1.5–4.9, p = 0.001; CC vs. TT: OR = 7.1, CI: 3.1–16.7, p ! 0.001), low pretreatment -GT/ALT ratio (OR = 2.5, CI: 1.7–3.3, p ! 0.001), age (OR = 0.96, CI: 0.94– 0.98, p = 0.001) and RVR (OR = 4.18, CI: 2.85–8.65, p ! 0.001) to be significantly related to treatment outcome. Patients with the IL28B rs12979860 CC genotype and a low pretreat- ment -GT/ALT ratio achieved the highest rate of a SVR with the highest predictive values (OR = 26.7, 95% CI: 10–71.1, p ! 0.0001). Conclusion: The pretreatment -GT/ALT ratio signif- icantly enhances the predictability of the IL28B genotype. Employing this combination will help to identify patients who will most likely benefit from an interferon- -based combination therapy in a no ntriaged ordinary setting. peerReviewed |
