Synthesis and NMR assignments of galactosylgloboside and its β- -GalNAc-(1→4)-α- -Gal-linked positional isomer in a conjugatable form

4)-alpha-D-Gal-linked positional isomer, were synthesized from 3III,4III-di-O-unprotected globotrioside and the trichloroacetimidate of beta-D-Gal-(1-->3)-beta-D-GalNPhth derivative. Glycosylation at both positions led to the formation of beta-D-GalNPhth-(1-->4)-alpha-D-Gal and beta-D-GalNPhth-(1-->3)-alpha-D-Gal-linked products in a ratio of 1:1 without selectivity. Complete NMR spectral assignments are also described -->
Jazyk: English
Přístupová URL adresa: https://explore.openaire.eu/search/publication?articleId=od______1674::a81da20333dc3859c87cf7ad661f1742
https://nrc-publications.canada.ca/eng/view/object/?id=3b1bc126-3ad7-4c2f-b9cf-54ca4c2e09c5
Rights: CLOSED
Přírůstkové číslo: edsair.od......1674..a81da20333dc3859c87cf7ad661f1742
Autor: Zou, Wei, Brisson, Jean-Robert, Larocque, Suzon, Gardner, Rebecca L., Jennings, Harold J.
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Popis: Two pentasaccharides suitable for conjugation, namely 3-aminopropyl glactosylgloboside and its beta-D-GalNAc-(1-->4)-alpha-D-Gal-linked positional isomer, were synthesized from 3III,4III-di-O-unprotected globotrioside and the trichloroacetimidate of beta-D-Gal-(1-->3)-beta-D-GalNPhth derivative. Glycosylation at both positions led to the formation of beta-D-GalNPhth-(1-->4)-alpha-D-Gal and beta-D-GalNPhth-(1-->3)-alpha-D-Gal-linked products in a ratio of 1:1 without selectivity. Complete NMR spectral assignments are also described
Databáze: OpenAIRE
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