A high proportion of cells carrying trisomy 12 is associated with a worse outcome in patients with chronic lymphocytic leukemia
| Autor: | González Gascón y Marín, Isabel, Puiggros Metje, Anna Maria, Espinet Solà, Blanca, Hernández, José-Ángel, Grupo Español de Leucemia Linfática Crónica (GELLC), Grupo Cooperativo Español de Citogenética Hematológica (GCECGH) |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Popis: | The prognosis of chronic lymphocytic leukemia (CLL) patients displaying trisomy 12 (+12) remains unclear. In this study, we analyzed the influence of the proportion of cells with +12, and other clinical and biologic factors, in time to first therapy (TTFT) and overall survival (OS), in 289 patients diagnosed with CLL carrying +12. Median OS was 129 months. One hundred seventy-four patients (60.2%) presented +12 in |
| Databáze: | OpenAIRE |
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