Quorum sensing and oral biofilm: an alternative for the prevention and treatment of oral diseases
| Autor: | Parga Martínez, Ana |
|---|---|
| Přispěvatelé: | Otero Casal, Ana María, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Avances en Bioloxía Microbiana e Parasitaria |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
oral microbiology
quorum quenching AHLs oral biofilm quorum sensing Investigación::24 Ciencias de la vida::2414 Microbiología::241408 Procesos microbianos [Materias] oral diseases Investigación::32 Ciencias médicas::3201 Ciencias clínicas::320103 Microbiología clínica [Materias] Investigación::24 Ciencias de la vida::2415 Biología molecular::241501 Biología molecular de microorganismos [Materias] |
| Popis: | The present thesis investigates the potential of inhibiting bacterial cell-cell communication, quorum sensing (QS), to modulate oral biofilm formation. The thesis evaluates the effect of a quorum quenching (QQ) enzyme that degrades N-acylhomoserine lactones, the QS signals of gram-negative bacteria, on in vitro polymicrobial oral biofilms. The potential interactions between AHLs and a gram-positive representative, Enterococcus faecalis, were also investigated. The results presented here support the translation of QQ strategies to in vivo trials for the modulation of oral biofilms. In addition, a more intricate role of AHLs on oral biofilm formation and interactions with gram-positive bacteria is proposed. 2024-02-17 |
| Databáze: | OpenAIRE |
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