Pharmaceutical compounding and drug repositioning from hospital pharmacy in situations of therapeutic gap

Autor:	Castro Balado, Ana
Přispěvatelé:	Otero Espinar, Francisco Javier, Fernández Ferreiro, Anxo, González Barcia, Miguel, Universidade de Santiago de Compostela. Escola de Doutoramento Internacional (EDIUS), Universidade de Santiago de Compostela. Programa de Doutoramento en Investigación e Desenvolvemento de Medicamentos
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	ocular cystinosis SARS-CoV-2 cysteamine 320902 Composición de medicamentos Inhaled ethanol 320908 Preparación de medicamentos Pharmaceutical compounding 320903 Evaluación de medicamentos
Popis:	This doctoral thesis focuses on offering therapeutic alternatives through pharmaceutical compounding and drug repositioning from the hospital pharmacy to cover therapeutic gaps. An ophthalmic compounded formulation of cysteamine in hyaluronic acid packaged in novel single-dose containers was developed for the treatment of ocular cystinosis. On the other hand, an inhaled compounded formulation of ethanol was developed for the treatment of SARS-CoV-2 infection, and subsequently studied for efficacy and safety in the phase II clinical trial ALCOVID-19. In both cases, appropriate galenic development and characterisation has been performed in conjunction with preclinical pharmacokinetic studies prior to appropriate translation into clinical practice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=od______1601::8e715f0b72b3d77da8d0dfe5c960f50a https://hdl.handle.net/10347/30750 Zobrazit plný text záznamu