Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine
| Autor: | Kohtala, S., Alitalo, O., Rosenholm, M., Rozov, S., Rantamäki, T. |
|---|---|
| Přispěvatelé: | Division of Pharmacology and Pharmacotherapy, Laboratory of Neurotherapeutics, Drug Research Program, SLEEPWELL Research Program, Medicum, INDIVIDRUG - Individualized Drug Therapy, Doctoral Programme Brain & Mind, Divisions of Faculty of Pharmacy |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Plasticity
Depression BLOOD-BRAIN-BARRIER Circadian 3112 Neurosciences PREFRONTAL CORTEX GLYCOGEN-SYNTHASE KINASE-3 SUPRACHIASMATIC NUCLEUS RESISTANT MAJOR DEPRESSION CLOCK GENE-EXPRESSION SLOW-WAVE ACTIVITY 317 Pharmacy BRIGHT LIGHT THERAPY Rapid-acting antidepressant LONG-TERM POTENTIATION Sleep Slow-wave sleep NEUROTROPHIC FACTOR |
| Popis: | Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid-acting antidepressant effects and summarize how diverse phenomena associated with ketamine’s antidepressant actions – such as cortical excitation, synaptogenesis, and involved molecular determinants – are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain. Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed, the acute pharmacological effects of a single ketamine treatment last for only a few hours, whereas the antidepressant effects peak at around 24 hours and are sustained for the following few days. Numerous studies have investigated the acute and long-lasting neurobiological changes induced by ketamine; however, the most dramatic and fundamental change that the brain undergoes each day is rarely taken into consideration. Here, we explore the link between sleep and circadian regulation and rapid -acting antidepressant effects and summarize how diverse phenomena associated with ketamine's antidepressant actions - such as cortical excitation, synaptogenesis, and involved molecular determinants - are intimately connected with the neurobiology of wake, sleep, and circadian rhythms. We review several recently proposed hypotheses about rapid antidepressant actions, which focus on sleep or circadian regulation, and discuss their implications for ongoing research. Considering these aspects may be the last piece of the puzzle necessary to gain a more comprehensive understanding of the effects of rapid-acting antidepressants on the brain. (c) 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|