| Autor: |
Keskin, Mutlu, Lähteenmäki, Hanna, Rathnayake, Nilminie, Räisänen, Ismo T., Tervahartiala, Taina, Pärnänen, Pirjo, Senisik, Ahmet Murat, Karacetin, Didem, Balkanay, Ayben Yentek, Heikkilä, Pia, Hagström, Jaana, Rautava, Jaana, Haglund, Caj, Gursoy, Ulvi Kahraman, Silbereisen, Angelika, Bostanci, Nagihan, Sorsa, Timo |
| Přispěvatelé: |
Department of Oral and Maxillofacial Diseases, Helsinki University Hospital Area, University of Helsinki, HUS Head and Neck Center, Clinicum, Medicum, Department of Pathology, HUSLAB, CAN-PRO - Translational Cancer Medicine Program, Research Programs Unit, HUS Abdominal Center, II kirurgian klinikka, Department of Surgery, Suu- ja leukakirurgian yksikkö |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Background: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck cancer (HNC) patients treated by radiotherapy. Research design and methods: Eleven patients, aged 28-74, diagnosed with HNC were included in the study. Complete periodontal and oral examinations were performed pre-radiotherapy and 1 month after radiotherapy. Mouthrinse samples (pre-radiotherapy, after 6 weeks of radiotherapy and 1 month after radiotherapy) were assayed by aMMP-8 point-of-care-kit (PerioSafe (R)/ORALyzer (R)) for aMMP-8 and ELISA for IL-6. Results: HNC radiotherapy had a deteriorating impact on the periodontium and a significant impact on periodontal biomarkers aMMP-8 and IL-6 and increased their levels in mouthrinse. Clinical-attachment-loss (CAL) (site of greatest loss: mean = 1.7 mm, range = 1-3 mm) corresponding to rapid progression of periodontitis. There was a positive repeated measures correlation (rmcorr = 0.667) between the aMMP-8 and IL-6 levels. Conclusions: Elevated aMMP-8 levels were observed 1 month after radiotherapy among some HNC patients suggesting a prolonged increased susceptibility to further periodontal tissue destruction. Currently available aMMP-8 point-of-care testing could be useful to monitor and assess quantitatively online and real-time the risk of deterioration of periodontal health during HNC radiotherapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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