Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases
| Autor: | Konovalova, Julia, Gerasymchuk, Dmytro, Parkkinen, Ilmari, Chmielarz, Piotr, Domanskyi, Andrii |
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| Přispěvatelé: | Institute of Biotechnology, Doctoral Programme in Integrative Life Science, Neuroscience Center, Doctoral Programme in Drug Research, Doctoral Programme in Biomedicine, Staff Services |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
DOWN-REGULATION
microRNA MIRNA BIOGENESIS Parkinson's disease neurodegeneration ROS Huntington's disease DOPAMINE TRANSPORTER translation regulation Alzheimer's disease AMYLOID PRECURSOR PROTEIN ALZHEIMERS-DISEASE ALPHA-SYNUCLEIN EXPRESSION PARKINSONS-DISEASE DICER EXPRESSION HUNTINGTONS-DISEASE oxidative stress 1182 Biochemistry cell and molecular biology ALS PROMOTES TAU PHOSPHORYLATION |
| Popis: | MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis increases neuronal vulnerability to cellular stress and may contribute to the development and progression of neurodegenerative diseases. All major neurodegenerative disorders are also associated with oxidative stress, which is widely recognized as a potential target for protective therapies. Albeit often considered separately, microRNA networks and oxidative stress are inextricably entwined in neurodegenerative processes. Oxidative stress affects expression levels of multiple microRNAs and, conversely, microRNAs regulate many genes involved in an oxidative stress response. Both oxidative stress and microRNA regulatory networks also influence other processes linked to neurodegeneration, such as mitochondrial dysfunction, deregulation of proteostasis, and increased neuroinflammation, which ultimately lead to neuronal death. Modulating the levels of a relatively small number of microRNAs may therefore alleviate pathological oxidative damage and have neuroprotective activity. Here, we review the role of individual microRNAs in oxidative stress and related pathways in four neurodegenerative conditions: Alzheimer's (AD), Parkinson's (PD), Huntington's (HD) disease, and amyotrophic lateral sclerosis (ALS). We also discuss the problems associated with the use of oversimplified cellular models and highlight perspectives of studying microRNA regulation and oxidative stress in human stem cell-derived neurons. |
| Databáze: | OpenAIRE |
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