| Autor: |
Pawar, Sachin A, Jabgunde, Amit M, Maguire, Glenn E. M., Dhavale, Dilip D, Govender, Thavendran, Kruger, Hendrik G, Albericio, Fernando |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
South African Journal of Chemistry, Volume: 67, Published: JAN 2014 |
| Popis: |
The γ-turn inducing sugar β-amino acid plays an important role in the formation of well-defined secondary structures of cyclic tetra- and pentapeptide. Two tetra- and one novel pentapeptide were synthesized from a sugar β-amino acid and the conformations of the compounds were established by NMR spectroscopy (EASY-ROESY) and compared with CD spectroscopic data. Although the γ-turn conformation was dominant for both tetra- and pentapeptide according to NMR spectroscopic analysis in DMSO, the pentapeptide exhibited the presence of a second conformation. CD spectroscopic results in methanol showed that the tetrapeptides have a γ-turn conformation, while the pentapeptide has a random structure. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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