| Autor: |
Paulin, Gregory A, Svenningsen, Sarah, Jobse, Brian N, Mohan, Sindu, Kirby, Miranda, Lewis, James F, Parraga, Grace |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
Medical Biophysics Publications |
| Popis: |
PURPOSE: To evaluate cystic fibrosis (CF) subjects over 4 years using (3) He magnetic resonance imaging (MRI), pulmonary function tests, and track hospitalization and physician visits. MATERIALS AND METHODS: Five CF adults provided written informed consent to an approved protocol and underwent MRI, spirometry, and plethysmography at baseline, 7 days, and 4 ± 1 years later. (3) He MRI ventilation defect percent (VDP) was generated for all subjects and timepoints. RESULTS: After 4 years, mean forced expiratory volume in 1 second / forced vital capacity (FEV1 /FVC) was lower (P = 0.01) in all subjects and there were no other pulmonary function test changes. Two CF adults showed significantly elevated (worse) (3) He VDP at baseline and after 4 years they had significantly greater (worsened) VDP (P = 0.02), without a significant FEV1 decline (P = 0.06) but with a greater number of exacerbations (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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