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Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020 The possible inhibitors of the programmed cell-1/programmed cell ligand-1(PD-1/PD-L1) system are going to be exposed in this review. For this purpose, what PD-1 means, where it can be found and why inhibit it are going to be exposed. The programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) are two protein system that form an immune checkpoint (ICP) that has been considered as a significant cancer therapy target. So, the first definition that has to be identified is cancer. Cancer is the name given to a group of related diseases in which abnormal cells divide without control and can invade nearby tissues. In all types of cancer, some of the body's cells begin to divide without stopping and spread to surrounding tissues, they have unlimited growth and expands locally by invasion and systematically by metastasis. Cancer can start almost anywhere in the human body, which is made up of trillions of cells. Normally, human cells grow and divide to form new cells as the body needs them and when normal cells die, new cells replace them. However, in cancer, this orderly process goes tousled. As cells become more and more abnormal, old or damaged cells survive when they should die, and new cells are form when they are not needed. These extra cells can divide without interruption and can form masses called tumors1 . This fact is called cancerogenesis (see Figure 1). |
