| Přispěvatelé: |
UCL - SSS/IREC/GYNE - Pôle de Gynécologie, UCL - Faculté de médecine et médecine dentaire, Andrade Amorim, Christiani, Vertommen, Didier, Marbaix, Etienne, Gallez , Bernard, Demoustier, Sophie, Fleury , Vincent, Mazzucchelli, Gabriel, Dolmans, Marie-Madeleine |
| Popis: |
While tissue engineering strategies for most organs stems primarily from a limited number of organ donors and side effects of immunosuppressive treatments, the demand for a transplantable artificial ovary (TAO) emerges as a procedure for fertility restoration in cancer survivors, who cannot benefit from available fertility restoration solutions. Indeed chemo- and radiotherapy can potentially be toxic for the ovaries, ultimately leading to sterility. This project represents the first attempt of ‘reverse engineering’ the human ovary. Reverse engineer biology means applying the engineering concept of taking apart a process or mechanism in order to understand it and re-engineer it (perhaps in a new way)—and applying it to the biological world. In this project, human ovarian cell’s microenvironment (matrisome) was deconstructed to better understand its proteomic, architectural and mechanical cues and their role in ovarian activity from prepuberty til menopause in order to reintegrate them into a biomimetic construct. Integrating these data will enable the TAO to be in the future a life changer for many female patients through making motherhood a possibility for them after cancer survival. (MED - Sciences médicales) -- UCL, 2021 |
