| Autor: |
Pitance, Laurent, Reychler, Gregory, Vecellio, Laurent, Leal, Teresinha, Reychler, Hervé, Liistro, Giuseppe, 20th ISAM (International Society for Aerosols in Medicine) Congress |
| Přispěvatelé: |
UCL - SSS/IREC/CARS - Computer Assisted Robotic Surgery, UCL - SSS/IREC/LTAP - Louvain Centre for Toxicology and Applied Pharmacology, UCL - SSS/IREC/PNEU - Pôle de Pneumologie, ORL et Dermatologie, UCL - (SLuc) Service de pneumologie, UCL - (SLuc) Service de médecine physique et de réadaptation motrice, UCL - (SLuc) Service de stomatologie et de chirurgie maxillo-faciale, UCL - (SLuc) Service de biochimie médicale |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Zdroj: |
Journal of Aerosol Medicine and Pulmonary Drug Delivery, Vol. 28, no.3, p. A14 (2015) |
| Popis: |
Rationale: Nebulized drugs are frequently administrated through tracheostomy in clinical routine. So far, the amount of drug deposited to the lung in these patients remains unknown. Objectives: To compare lung deposition of amikacin in 2 conditions: in spontaneously breathing through a tracheostomy and through the mouth. Methods: Lung delivery was measured by amikacin urinary drug concentration in nine patients who were transitory tracheostomized for the need of a head and neck oncologic surgery. Patients performed two nebulization sessions: with and without tracheostomy using an adapted jet nebulizer (Sidestream). Measurements and main results: Lung deposition was similar with the two conditions of nebulization (6.5 – 2.5 vs. 6.3 – 2.0% of the nominal mass of amikacin respectively for MB and TB; p¼0.87). Duration of nebulization was also comparable (19.7 – 1.6 vs. 20.1 – 1.8 min respectively for mouth and tracheostomy breathing; p¼0.92). The half-life and elimination rate constant were not different between the two settings. Conclusions: The nebulized therapy can be administered in spontaneously breathing tracheostomized patients with a similar amount of drug deposited in the lung compared with untracheostomized spontaneously breathing patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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