| Autor: |
Carvalho, Luísa C. R., Lourenço, Ana, Ferreira, Luísa Maria, Branco, Paula Sério |
| Přispěvatelé: |
DQ - Departamento de Química |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Popis: |
co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265). The authors would like to thank Hovione FarmaCiencia SA for financial support. Tofacitinib is a Janus activated kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis and active psoriatic arthritis. Its synthesis normally involves long synthetic sequences due to the chirality associated to the piperidine ring. This review is a comprehensive analysis of the different synthetic methods used to prepare this active pharmaceutical ingredient (API), covering the related journal and patent literature. authorsversion published |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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