| Autor: |
Gomes, Diana, Silvestre, Samuel, Duarte, Ana Paula, Venuti, Aldo, Soares, Christiane P., Passarinha, Luís, Sousa, Ângela |
| Přispěvatelé: |
UCIBIO - Applied Molecular Biosciences Unit, DCV - Departamento de Ciências da Vida, DQ - Departamento de Química |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Funding Information: Funding: This work was supported by the Foundation for Science and Technology (FCT), through funds from the State Budget and by the European Regional Development Fund through the “Pro-grama Operacional Regional do Centro (Centro 2020)—Sistema de Apoio à Investigação Científica e Tecnológica—Programas Integrados de IC&DT” (Project Centro-01-0145-FEDER-000019—C4—Centro de Competências em Cloud Computing) and the project ref: UIDB/00709/2020. This work was also supported by national funds from FCT—Fundação para a Ciência e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences—UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy—i4HB. D. Gomes also acknowledges the doctoral fellowship from FCT ref: 2020.06792.BD. Funding Information: This work was supported by the Foundation for Science and Technology (FCT), through funds from the State Budget and by the European Regional Development Fund through the ?Pro-grama Operacional Regional do Centro (Centro 2020)?Sistema de Apoio ? Investiga??o Cient?fica e Tecnol?gica?Programas Integrados de IC&DT? (Project Centro-01-0145-FEDER-000019?C4?Centro de Compet?ncias em Cloud Computing) and the project ref: UIDB/00709/2020. This work was also supported by national funds from FCT?Funda??o para a Ci?ncia e a Tecnologia, I.P., in the scope of the project UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences?UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy?i4HB. D. Gomes also acknowledges the doctoral fellowship from FCT ref: 2020.06792.BD. Institutional Review Board Statement: Not applicable. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Cervical cancer (CC) is the fourth most common pathology in women worldwide and presents a high impact in developing countries due to limited financial resources as well as difficulties in monitoring and access to health services. Human papillomavirus (HPV) is the leading cause of CC, and despite the approval of prophylactic vaccines, there is no effective treatment for patients with pre-existing infections or HPV-induced carcinomas. High-risk (HR) HPV E6 and E7 oncoproteins are considered biomarkers in CC progression. Since the E6 structure was resolved, it has been one of the most studied targets to develop novel and specific therapeutics to treat/manage CC. Therefore, several small molecules (plant-derived or synthetic compounds) have been reported as blockers/inhibitors of E6 oncoprotein action, and computational-aided methods have been of high relevance in their discovery and development. In silico approaches have become a powerful tool for reducing the time and cost of the drug development process. Thus, this review will depict small molecules that are already being explored as HR HPV E6 protein blockers and in silico approaches to the design of novel therapeutics for managing CC. Besides, future perspectives in CC therapy will be briefly discussed. publishersversion published |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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