The angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases
| Autor: | Fraga-Silva, Rodrigo A, Da Silva, Danielle G, Montecucco, Fabrizio, Mach, François, Stergiopulos, Nikolaos, da Silva, Rafaela F, Santos, Robson A S |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
ddc:616
Renin-Angiotensin System/drug effects/physiology Proto-Oncogene Proteins/physiology Receptor Angiotensin Type 1/physiology Angiotensin II Type 1 Receptor Blockers/pharmacology Receptors G-Protein-Coupled/physiology Models Cardiovascular Humans Angiotensin-Converting Enzyme Inhibitors/pharmacology Hemostasis/drug effects/physiology Peptidyl-Dipeptidase A/physiology Thrombosis/blood/drug therapy/physiopathology |
| Zdroj: | Thrombosis and Haemostasis, Vol. 108, No 6 (2012) pp. 1089-1096 |
| ISSN: | 0340-6245 |
| Popis: | Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidity and mortality. Remarkable effort has been made to identify new drug targets. There is growing evidence indicating that the recently described counter-regulator axis of the renin-angiotensin system (RAS), composed of Angiotensin-Converting Enzyme 2 (ACE2), Angiotensin-(1-7) and the Mas receptor, has protective effects against thrombosis. In addition, it could be considered as a promising target for treating or preventing this disease. In this narrative review, we focused on the recent findings of the role of the ACE2/Angiotensin-(1-7)/Mas axis on the haemostatic process and its therapeutic potential. |
| Databáze: | OpenAIRE |
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