Cell adhesion by integrins
| Autor: | Bachmann, Michaël, Kukkurainen, Sampo, Hytönen, Vesa P, Wehrle-Haller, Bernhard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Signal Transducing/metabolism
Mechanotransduction Protein Conformation Cell Membrane/metabolism Adaptor Proteins Molecular Extracellular Matrix/metabolism Phosphoproteins/metabolism Structure-Activity Relationship Intracellular Signaling Peptides and Proteins/metabolism Models Cell Adhesion Integrins/chemistry/metabolism Animals Humans Cellular ddc:612 Cell Proliferation |
| Zdroj: | Physiological Reviews, Vol. 99, No 4 (2019) pp. 1655-1699 |
| ISSN: | 0031-9333 |
| Popis: | Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellular signaling, but are also taking center stage in many physiological and pathological conditions. In this review, we provide some historical, structural, and physiological notes so that the diverse functions of these receptors can be appreciated and put into the context of the emerging field of mechanobiology. We propose that the exciting journey of the exploration of these receptors will continue for at least another new generation of researchers. |
| Databáze: | OpenAIRE |
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