| Autor: |
Nicolaou, K. C., Hepworth, David, King, N. Paul, Finlay, M. Raymond V., Scarpelli, Rita, Pereira, M. Manuela A., Bollbuck, Birgit, Bigot, Antony, Werschkun, Barbara, Winssinger, Nicolas |
| Jazyk: |
angličtina |
| Rok vydání: |
2000 |
| Předmět: |
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| Zdroj: |
Chemistry-A European Journal, Vol. 6, No 15 (2000) pp. 2783-2800 |
| ISSN: |
0947-6539 |
| Popis: |
The macrolactonization-based strategy for the total synthesis of epothilones has been streamlined and improved to a high level of efficiency and stereoselectivity. This strategy has been applied to the construction of vinyl iodide 19 which served as a common intermediate for the synthesis of a series of natural and designed epothilones including an epothilone B10 (3), epothilone F (5), 16-desmethylepothilone B (14), pyridine epothilones 57 a–57 g, dimeric epothilones 59 and 61, and benzenoid epothilones 63 a–63 g. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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